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Radar level sensors ensure optimal flow in slurry and UF tanks

VEGA measuring systems are being designed more and more with hygiene in mind, in order to reliably protect closed biosystems from microbes.

VEGA measuring systems are being designed more and more with hygiene in mind, in order to reliably protect closed biosystems from microbes.

Level measurement based on 80-GHz radar technology is independent of disturbing factors such as the vessel internals, foaming or build up on the reactor walls.

Hardly anything in today's pharmaceutical industry  is like it was 10 or 20 years ago. During this period, modern biotechnology has significantly improved medicines and opened up new possibilities for them as well. Many medicines are now highly specialized and with increasing frequency, personalized. Measurement and control technology plays a special role in this area: numerous process parameters are continuously maintained at precisely specified values, because the cultured organisms only thrive when they live under ideal conditions. If the values deviate, reproduction is slowed down or the microorganisms even die. Every bioprocess runs differently and according to its own rules. What all bioprocesses have in common, however, is that they are strongly influenced by external factors. The job of measurement technology is to monitor these variables and ensure that the culture environment always maintains the proper values.

The extremely short wavelength of VEGAPULS 64 radar sensors enables a high-precision level control throughout the entire production process.

At Lonza, highly accurate VEGAPULS 64 radar level sensors measure this solution in the so-called slurry tanks. Their measuring results form the basis for an exact concentration during "packing". The more accurate the level measurement, the more accurately the pack height can be calculated or estimated. Exact level readings influence both the yield and quality of these highly individualised and protected substances.

In the UF tank, ultrafiltration or diafiltration takes place, in which solutions are concentrated into widely varying volumes. VEGAPULS 64 radar sensors continuously ensure the correct level, i.e. volume, in the stirring tank, which can fluctuate by several hundred litres during a batch run. Part of the filtration process is the periodically repeated addition and removal of small quantities of RedOx buffering solution. These level changes are also precisely monitored and controlled by means of level measurement, in order to ensure the desired volume spectrum.

Until recently, the Swiss company had been using conventional differential pressure systems for measurement in bioprocesses. When the company put the 80-GHz radar sensor VEGAPULS 64 into operation - it was the first non-contact measuring system that could be installed so quickly and easily – no one had seen anything like it before. Completely without changes to existing equipment, and without additional accessories or fittings. The high-frequency radar instrument now detects the volume with a measurement accuracy of +/-1 mm. Another advantage of the radar level sensor: If retrofitted, VEGAPULS 64 can be installed on existing mounting sockets, making only minimal alterations necessary. Reliable measured values are then available in no time at all.

Lonza is combining the principles of modularity and technology independence to realize groundbreaking bioprocesses such as Ibex™ Solutions, which will allow it to engage with total flexibility in the future-oriented "Mammalian", biotech sector i.e. mammalian cell culture production services.

Application in the pharmaceutical industry – the advantages of VEGAPULS 64 at a glance:


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